Solid‐Phase Peptide Macrocyclization and Multifunctionalization via Dipyrrin Construction

We introduce a new and highly efficient synthetic protocol towards multifunctional fluorescent cyclopeptides by solid-phase peptide macrocyclization via dipyrrin construction, with full scope of proteinogenic amino acids different ring sizes. Various bicyclic peptides can be created dipyrrin-based crosslinking double dipyrrin-ring formation. The embedded either transformed to BODIPY then utilized as cancer-selective targeted protein imaging probe in vitro, or directly employed selective metal sensor aqueous media. This work provides valuable addition the toolbox, blueprint for development linkers wide range potential bioapplications.